Feburix is a medicine that contains an active substance called Febuxostat. Febuxostat is the first nonpurine inhibitor of xanthine oxidase, and there by reduces the formation of xanthine and uric acid. Feburix at a daily dose of 80mg or 120mg was more effective than allopurinol at standard of 300mg daily dose in lowering serum urate level.
It is more than 80% absorbed following oral administration. Maximum concentration is reached in approximately 1 hour. Feburix is extensively metabolized in the liver. All the drug and metabolites appear in the urine although less than 5% appears as unchanged drug. Because it is highly metabolized to inactive metabolites, no dosage adjustment is necessary for patient with renal impairment.
Precaution:
You should not use febuxostat if you are allergic to it, or if you also use: azathioprine mercaptopurine. Theophylline. Tell your doctor if you have ever had: liver or kidney disease, heart disease, a heart attack or stroke, cancer, Lesch-Nyhan syndrome, organ transplant (kidney, liver, lung, and heart).
Pregnancy and breastfeeding:
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Your pharmacist can provide more information about Feburix.
How to use:
Starting dosage is usually 40mg once daily can be taken without regard food ,for the treatment of chronic gout -If serum uric acid level is greater than 6 mg/dL after 2 weeks, increase the dose to 80 mg orally once a day Maintenance dose: 40 to 80 mg orally once a day -Maximum dose: 80 mg/day
-Use of this drug should occur after an acute gout flare subsides.
18 years of age or less have not been done.
Renal Dose Adjustments Mild to Moderate Renal Dysfunction (CrCl 30 to 89 mL/min) No adjustment recommended Severe Renal Dysfunction (CrCl 15 to 29 mL/min): Maximum daily dose should be limited to 40 mg/day Liver Dose Adjustments Mild to Moderate Liver Dysfunction): No adjustment recommended. Severe Liver Dysfunction: Use with caution

Use with other medications :( interactions)
Azathioprine: Feburix may increase the serum concentration of Azathioprine. Risk X: Avoid combination. Didanosine: Feburix may increase the serum concentration of Didanosine. Risk X: Avoid combination Mercaptopurine: Feburix may increase the serum concentration of Mercaptopurine. Risk X: Avoid combination
Theophylline Derivatives: Feburix may increase serum concentrations of the active metabolite(s) of Theophylline Derivatives. Specifically, concentrations of 1-methylxanthine, a metabolite of unknown clinical importance, may become elevated. Management: The U.S. febuxostat labeling recommends using caution in patients receiving concomitant theophylline due to risks of increased theophylline metabolite exposure. The Canadian febuxostat labeling contraindicates its use with theophylline. Exceptions: Dyphylline. Risk C: Monitor therapy
Side effect:
As with allopurinol, prophylactic treatment with colchicine or NSAIDS should start at the beginning of treatment to avoid gout flares. The most frequent treatment related adverse event are liver function abnormalities, diarrhea, headache and nausea. Feburix appears to be tolerated in patient with history of allopurinol intolerance.
Feburix may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking feburix .Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Call your doctor at once if you have:
•heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating liver problems--stomach pain (upper right side), unusual tiredness, dark urine, jaundice (yellowing of the skin or eyes); or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.