Vitamin D refers to a group of fat soluble secosteroids responsible for increasing intestinal
Absorption of calcium, magnesium, and phosphate, and multiple other biological effects in
human, the most important compounds in this group are D3 (also known as cholecalciferolan)
and vitamin D2 (Ergocalciferol) these two vitamin can be ingested from the diet and supplement,
but only a few foods contain vitamin D. Vitamin D from diet or skin synthesis is biologically
Inactive, conversion (hydroxylation) in the liver, kidney is required for activation.
Special precaution &warning:
Pregnancy& breast feeding : Vitamin D is likely safe during pregnancy and breast-feeding when used in daily amount below 4000 unit. Do not use higher doses. Vitamin D is possibly unsafe when used in higher amounts during pregnancy or while breast-feeding. Using higher doses might cause serious harm to the infant.
Kidney disease: Vitamin D may increase calcium level s and increase the risk of hardening of arteries in people with serious kidney disease. This must be balanced with the need to prevent renal osteodystrophy, a bone disease that occurs when the kidney fail to maintain the proper levels should be monitored carefully in people with kidney disease.
High levels of calcium in the blood: taking vitamin D could make this condition worse.
Atherosclerosis: taking vitamin D could make this condition worse.
Sarcoidosis: vitamin D may increase calcium levels in people with sarcoidosis. This could lead to kidney stones and other problems. Use vitamin D cautiously.
Histoplasmosis: vitamin D may increase calcium level in people with Histoplasmosis this could lead to kidney stones and other problems. Use vitamin D cautiously.
Hyperparathyroidism: vitamin D may increase calcium levels in people with hyperparathyroidism. use vitamin D cautiously.
Lymphoma: vitamin D may increase calcium level s in people with lymphoma. This could be lead to kidney stones and other problems. Use vitamin D cautiously.
Tuberculosis: vitamin D might increase calcium levels in people with tuberculosis. This might result in complications such as kidney stones.
Use and doze:
Vitamin D is used for preventing and treating Rickets, a disease that is caused by not having enough Vitamin D (vitamin D deficiency). Vitamin D is also used for treating weak bones (osteoporosis) , bone pain (osteomalacia), bone loss in people with a condition called hyperparathyroidism, and an inherited disease (osteogenesis imperfect) in which the bones are especially brittle and easily broken. It is also used for preventing falls and fractures in people at risk for osteoporosis, and preventing low calcium and bone loss (renal osteodystrophy) in people with kidney failure. Vitamin D is used for conditions of the heart and blood vessels, including high blood pressure and high cholesterol. It is also used for diabetes, obesity, muscle weakness, multiple sclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), asthma, bronchitis, premenstrual syndrome (PMS) and tooth and gum disease. Some people use vitamin D for skin condition including Vittiligo Scleroderma, Psoriasis, Actinic Keratosis, and Lupus Vulgaris.it is also used for boosting the immune system, preventing autoimmune disease, and preventing cancer. Because vitamin D is involved in regulating the level of minerals such as phosphorous and calcium, it is used for conditions caused by low levels of phosphorous (familial hypophosphatemia and Franconia syndrome) and low levels of calcium (hyperparathyroidism and pseudohypoparathyroidism).
There is evidence that vitamin D deficiency may increase the risk of many diseases:
Cancer, including colon, prostate, breast, and pancreatic cancer.
Autoimmune disease, including type 1 and type2 diabetes, rheumatoid, arthritis, crohn’s disease and multiple sclerosis
Heart disease
Dosage:
The new guidelines recommend different doses of vitamin D for those at risk of vitamin D deficiency:
•Age 0 to 1 year: 400 to 1,000 International Units (IU) daily
•Age 1 to 18 years: 600 to 1,000 IU daily
•All adults over age 18: 1,500 to 2,000 IU daily
•Pregnant or nursing women under age 18: 600 to 1,000 IU daily
•Pregnant or nursing women over age 18: 1,500 to 2,000 IU daily
Use with other medicines (interactions)
Aluminum interacts with VITAMIN D Aluminum is found in most antacids. Vitamin D can increase how much Aluminum the body absorbs. This interaction might be a problem for people with kidney disease. Take vitamin D two hours before, or for hours after antacids.
Calcipotriene interacts with vitamin D; Calcipotriene is a drug that is similar to vitamin D. taking vitamin D along with calcipotriene might increase the effects and side effects of calcpotriente. Avoid taking vitamin D supplements if you are taking calcipotriente.
Digoxin: vitamin D helps body absorb calcium. Calcium can affect the heart. Digoxin is used to help heart beat stronger. Taking vitamin along with Digoxin might increase the effects of Digoxin and lead to an irregular heartbeat. If you are taking Digoxin talks to your doctor before taking vitamin D supplement.
Diltiazem: taking large amount of vitamin D along with Diltiazem might decrease the effectiveness of Diltiazem.
Verapamil: do not take large amount of vitamin D if you are taking verapamil.
Thiazides: interact with vitamin D. it increase the amount of calcium in the body. Taking large amount of vitamin D along with them might cause to be too much calcium in the body.
Cimetidine: the body changes vitamin D into form that it can use. Cimetidine might decrease how well the body changes vitamin D works. But this interaction probably isn’t important for most people.
Heparin &low molecular weight heparin: they slow blood clotting and can increase the risk of breaking a bone when used for a long period of time. People taking these medications should eat a diet rich of calcium and vitamin D.
Side effects & safety:
Vitamin D is likely safe when taking by mouth or given as a shot into muscle in recommended amount. Most people do not commonly experience side effects with vitamin D, unless too much is taken . some side effect s of taking too much vitamin D include weakness, fatigue , sleepless, headache, loss of appetite, dry mouth, metallic taste, nausea, vomiting and others.
We encourage you to talk to your healthcare providers (doctor, pharmacist, registered dietitian) about your interest in, question about, or use of dietary supplement and what may be best for your overall health.